Author:
Anggraheni Sufahmi,Humaidah Nurul,Jailani Freih,Nurhaliza Nadiah,Indarto Risky Rahmad
Abstract
The coronavirus, known to exist in humans and livestock for an extended period, includes variants such as the infectious bronchitis (IB) virus in chickens. As a single-stranded RNA virus, coronaviruses are prone to mutations. Patikan Kebo (Euphorbia hirta L) is a medicinal herb containing various compounds like Flavonoids, Mirisil, Alkaloids, Laraserol, Hentriakontanol, and Komositin, known for their antibacterial, antiviral, and anti-worm properties. This study aimed to evaluate the toxicity of Patikan Kebo extract on Chicken Embryo Eggs (TAB) and assess its antiviral potential against the chicken AI coronavirus. The experimental approach involved three concentrations of Patikan Kebo extract (0.01% - P1, 0.1% - P2, 1% - P3), a control group without Patikan Kebo extract (K+), and a control group without the virus (K-). Data analysis was conducted using ANOVA and Tukey HSD in the SPSS program. The results from ANOVA indicated that the dose of Patikan Kebo significantly impacted (P<0.05) its antiviral activity against the IB virus. The average HA Titer 2 (Log2) demonstrated a 47% reduction in viral activity. In conclusion, the most effective herbal antiviral dose against the IB virus was determined to be 0.1% Patikan Kebo extract.
Publisher
Universitas Islam Lamongan
Subject
Computer Networks and Communications,Hardware and Architecture,Software
Reference23 articles.
1. Ministry of Health, "Corona Virus Mutations Spread Faster, People Are Called to Tighten Health Protocol Discipline,"www. kemkes.go.id2020
2. A. Susiloet al., “Review of Current Literatures Mutations and Variants of Coronavirus Disease 2019 (COVID-19): A Review of Recent Literature,†J. Indonesian Internal Medicine, vol. 9, no. 1, pp. 59–81, 2022.
3. NLP Indi Dharmayanti and R. Indriani, “Identification and Characterization of Infectious Bronchitis Virus (IBV) in Indonesia,â€J. Biol. Indonesia., vol. 13, no. 1, pp. 53–60, 2017, doi:10,47349/jbi/13012017/53.
4. NS Yuliani and GYI Sakan, "Antibody Titer Responses in Broiler Chickens Vaccinated with Nd and Given Herbs,"Partners, vol. 23, no. 2, p. 696, 2018, doi:10.35726/jp.v23i2.312.
5. “66366-EN-benefits-extract-ethanol-patikan-kebo-euph.pdf.â€