Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases-Reference-Cited by-同舟云学术

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Published:2017-02-10 Issue:4 Volume:60 Page:1247-1261
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Harris Philip A.^ORCID,Berger Scott B.,Jeong Jae U.,Nagilla Rakesh,Bandyopadhyay Deepak,Campobasso Nino,Capriotti Carol A.,Cox Julie A.,Dare Lauren,Dong Xiaoyang,Eidam Patrick M.,Finger Joshua N.,Hoffman Sandra J.,Kang James,Kasparcova Viera,King Bryan W.,Lehr Ruth,Lan Yunfeng,Leister Lara K.,Lich John D.,MacDonald Thomas T.¹,Miller Nathan A.,Ouellette Michael T.,Pao Christina S.,Rahman Attiq,Reilly Michael A.,Rendina Alan R.,Rivera Elizabeth J.,Schaeffer Michelle C.,Sehon Clark A.,Singhaus Robert R.,Sun Helen H.,Swift Barbara A.,Totoritis Rachel D.,Vossenkämper Anna¹,Ward Paris,Wisnoski David D.,Zhang Daohua,Marquis Robert W.,Gough Peter J.,Bertin John

Affiliation:

1. Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London, E1 2AD London, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01751

Reference31 articles.

1. Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

2. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

3. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

4. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

5. The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

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