Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas-Reference-Cited by-同舟云学术

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

Published:2016-10-28 Issue:21 Volume:59 Page:9928-9941
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vaswani Rishi G.¹,Gehling Victor S.¹,Dakin Les A.¹,Cook Andrew S.¹,Nasveschuk Christopher G.¹,Duplessis Martin¹,Iyer Priyadarshini¹,Balasubramanian Srividya¹,Zhao Feng¹,Good Andrew C.¹,Campbell Robert¹,Lee Christina¹,Cantone Nico¹,Cummings Richard T.¹,Normant Emmanuel¹,Bellon Steven F.¹,Albrecht Brian K.¹,Harmange Jean-Christophe¹,Trojer Patrick¹,Audia James E.¹,Zhang Ying¹,Justin Neil¹,Chen Shuyang¹,Wilson Jon R.¹,Gamblin Steven J.¹

Affiliation:

1. Constellation Pharmaceuticals, Inc., 215 First Street, Suite 200, Cambridge, Massachusetts 02142, United States

Funder

Medical Research Council

Wellcome Trust

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01315