Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold-Reference-Cited by-同舟云学术

Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold

Published:2017-03-17 Issue:7 Volume:60 Page:2697-2717
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li He¹²,Huang Qi¹²,Chen Cheng¹³,Xu Bin³^ORCID,Wang He-Yao¹,Long Ya-Qiu¹^ORCID

Affiliation:

1. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b01357

Reference37 articles.

1. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

2. Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

3. GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space

4. Advances in Small-Molecule GPR40 Agonists for Treatment of Type 2 Diabetes Mellitus

5. Recent developments in the discovery of FFA1 receptor agonists as novel oral treatment for type 2 diabetes mellitus

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthetic GPR40/FFAR1 agonists: An exhaustive survey on the most recent chemical classes and their structure-activity relationships;European Journal of Medicinal Chemistry;2024-01

2. Mesoporous Tio2 Supported Synthesis of Aryl Propionic Acid Derivatives, and Mild Peroxides, Organometallic Catalyst Free Oxidative Cleavage of C=C in Electron Deficient Olefins;2024

3. Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into β-position to the carboxylic acid;European Journal of Medicinal Chemistry;2023-05

4. Discovery of a structurally novel, potent, and once-weekly free fatty acid receptor 1 agonist for the treatment of diabetes;European Journal of Medicinal Chemistry;2023-01

5. 2‐Iodothiophene;Encyclopedia of Reagents for Organic Synthesis;2022-07-26