Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress

Author:

Duan Hongliang1,Lee Jae Wook23,Moon Sung Won2,Arora Daleep1,Li Yu4,Lim Hui-Ying5,Wang Weidong14

Affiliation:

1. Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, United States

2. Natural Product Research Center, Korea Institute of Science and Technology, 679 Saimdang-ro, Gangneung, Gangwon-do 210-340, Republic of Korea

3. Department of Biological Chemistry, Korea University of Science and Technology (UST), Daejeon 305-333, Republic of Korea

4. Department of Medicine, Division of Endocrinology, Department of Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, 941 Stanton L. Young Boulevard, Oklahoma City, Oklahoma 73104, United States

5. Department of Physiology, The University of Oklahoma Health Science Center, 941 Stanton L. Young Boulevard, Oklahoma City, Oklahoma 73104, United States

Funder

Korea Institute of Science and Technology

Oklahoma Center for the Advancement of Science and Technology

U.S. Department of Health and Human Services

National Research Council of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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