Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes

Author:

Li Yao1ORCID,Shi Zongjun1,Chen Lei1,Zheng Suxin1,Li Sheng1,Xu Bo1,Liu Zhenhong1,Liu Jianyu1,Deng Chongyang1,Ye Fei1

Affiliation:

1. Haisco Pharmaceuticals Group Co. Ltd., 136 Baili Road, Wenjiang District, Chengdu 611130, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference42 articles.

1. IDF Diabetes Atlas,7thed.International Diabetes Federation:Brussels, 2015; http://www.idf.org/diabetesatlas(accessed February 25, 2017).

2. The global implications of diabetes and cancer

3. Diabetes: Fact Sheet;World Health Organization:Geneva, 2016; http://www.who.int/mediacentre/factsheets/fs312/en(accessed February 25, 2017).

4. Type 2 diabetes: principles of pathogenesis and therapy

5. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.

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