Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na+/H+ Exchanger Type 3 (NHE3)-Reference-Cited by-同舟云学术

Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na+/H+ Exchanger Type 3 (NHE3)

Published:2016-09-22 Issue:19 Volume:59 Page:8812-8829
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rackelmann Nils¹,Matter Hans¹,Englert Heinrich¹,Follmann Markus¹,Maier Thomas¹,Weston John¹,Arndt Petra¹,Heyse Winfried¹,Mertsch Katharina¹,Wirth Klaus¹,Bialy Laurent¹

Affiliation:

1. Sanofi-Aventis Deutschland GmbH, R&D, D-65926, Frankfurt am Main, Germany

Funder

Sanofi

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00624

Reference90 articles.

1. Regulatory Binding Partners and Complexes of NHE3

2. Evolutionary origins of eukaryotic sodium/proton exchangers

3. Physical and Genetic Mapping of a Human Apical Epithelial Na+/H+ Exchanger (NHE3) Isoform to Chromosome 5p15.3

4. Role of Na+-H+ antiport in rat proximal tubule NaCl absorption

5. Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption.

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