Discovery and Rational Design of Pteridin-7(8H)-one-Based Inhibitors Targeting FMS-like Tyrosine Kinase 3 (FLT3) and Its Mutants-Reference-Cited by-同舟云学术

Discovery and Rational Design of Pteridin-7(8H)-one-Based Inhibitors Targeting FMS-like Tyrosine Kinase 3 (FLT3) and Its Mutants

Published:2016-06-22 Issue:13 Volume:59 Page:6187-6200
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Deheng¹,Yang Yu¹,Lyu Jiankun¹,Zhou Wei¹,Song Wenlin¹,Zhao Zhenjiang¹,Chen Zhuo¹,Xu Yufang¹,Li Honglin¹

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China

Funder

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

Fok Ying Tong Education Foundation

Shanghai Municipal Education Commission

National Natural Science Foundation of China

Shanghai Committee of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00374

Reference42 articles.

1. The role of FLT3 in haematopoietic malignancies

2. Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

3. Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

4. FLT3 mutations in acute myeloid leukemia cell lines

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