Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase-Reference-Cited by-同舟云学术

Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase

Published:2016-09-29 Issue:19 Volume:59 Page:9269-9275
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Luciani Rosaria¹,Saxena Puneet¹,Surade Sachin²,Santucci Matteo¹,Venturelli Alberto¹³,Borsari Chiara¹,Marverti Gaetano⁴,Ponterini Glauco¹,Ferrari Stefania¹,Blundell Tom L.²,Costi Maria Paola¹

Affiliation:

1. Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi, 103, 41125 Modena, Italy

2. Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, United Kingdom

3. Tydock Pharma srl, Strada Gherbella 294/B, 41126 Modena, Italy

4. Department of Biomedical Sciences, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Campi, 287, 41125 Modena, Italy

Funder

Seventh Framework Programme

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00977

Reference33 articles.

1. Trends in tuberculosis incidence and their determinants in 134 countries

2. The Development and Impact of Tuberculosis Vaccines

3. Challenges and opportunities in developing novel drugs for TB

4. Nitroimidazoles for the treatment of TB: past, present and future

5. An Alternative Flavin-Dependent Mechanism for Thymidylate Synthesis

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