Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology-Reference-Cited by-同舟云学术

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology

Published:2016-12-22 Issue:1 Volume:60 Page:100-118
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mejdrová Ivana¹²,Chalupská Dominika¹,Plačková Pavla¹,Müller Christin³,Šála Michal¹,Klíma Martin¹,Baumlová Adriana¹,Hřebabecký Hubert¹,Procházková Eliška¹,Dejmek Milan¹,Strunin Dmytro¹,Weber Jan¹,Lee Gary²,Matoušová Marika¹,Mertlíková-Kaiserová Helena¹,Ziebuhr John³,Birkus Gabriel⁴,Boura Evzen¹^ORCID,Nencka Radim¹^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic

2. Department of Chemistry of Natural Compounds, Institute of Chemical Technology Prague, Technická 5, Prague 166 28, Czech Republic

3. Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, D-35392 Giessen, Germany

4. Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States

Funder

Grantová Agentura Ceské Republiky

Akademie Ved Ceské Republiky

Directorate-General for Research and Innovation

Gilead Sciences

Deutsches Zentrum für Infektionsforschung

Publisher

American Chemical Society (ACS)

Subject