BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen

Author:

Ayoub Alex M.1,Hawk Laura M. L.1,Herzig Ryan J.2,Jiang Jiewei2,Wisniewski Andrea J.2,Gee Clifford T.1,Zhao Peiliang2,Zhu Jin-Yi3,Berndt Norbert3,Offei-Addo Nana K.4,Scott Thomas G.4,Qi Jun4,Bradner James E.4,Ward Timothy R.2,Schönbrunn Ernst3,Georg Gunda I.2ORCID,Pomerantz William C. K.1ORCID

Affiliation:

1. Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States

2. Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55455, United States

3. Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, United States

4. Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, 360 Longwood Avenue, Boston, Massachusetts 02215, United States

Funder

Division of Chemistry

National Institute of Child Health and Human Development

University of Minnesota

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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