Design, Synthesis, and Evaluation of [18F]T-914 as a Novel Positron-Emission Tomography Tracer for Lysine-Specific Demethylase 1-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of [18F]T-914 as a Novel Positron-Emission Tomography Tracer for Lysine-Specific Demethylase 1

Published:2021-08-23 Issue:17 Volume:64 Page:12680-12690
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Matsuda Satoru¹^ORCID,Hattori Yasushi¹^ORCID,Matsumiya Kouta²,McQuade Paul³,Yamashita Tohru¹,Aida Jumpei¹^ORCID,Sandiego Christine M.⁴,Gouasmat Alexandra⁴,Carroll Vincent M.⁴,Barret Olivier⁵,Tamagnan Gilles⁶,Koike Tatsuki¹^ORCID,Kimura Haruhide¹

Affiliation:

1. Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

2. Drug Metabolism and Pharmacokinetics Research Laboratories, Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

3. Quantitative Translational Science − Imaging, Takeda Pharmaceutical Company Limited, 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States

4. Invicro, A Konica Minolta Company, 60 Temple Street, Suite 8A, New Haven, Connecticut 06510, United States

5. Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, 92265 Fontenay-aux-Roses, France

6. XingImaging LLC, 760 Temple Street, New Haven, Connecticut 06510, United States

Funder

Takeda Pharmaceutical Company

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00653

Reference22 articles.

1. Early Life Programming and Neurodevelopmental Disorders

2. Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

3. A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors

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5. T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice

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