Discovery of New Potent Positive Allosteric Modulators of Dopamine D2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide-Reference-Cited by-同舟云学术

Discovery of New Potent Positive Allosteric Modulators of Dopamine D2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide

Published:2021-04-16 Issue:9 Volume:64 Page:6209-6220
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sampaio-Dias Ivo E.¹^ORCID,Reis-Mendes Ana²,Costa Vera Marisa²,García-Mera Xerardo³,Brea José⁴,Loza María Isabel⁴,Pires-Lima Beatriz L.¹,Alcoholado Cristina⁵,Algarra Manuel⁶^ORCID,Rodríguez-Borges José E.¹

Affiliation:

1. LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal

2. UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal

3. Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain

4. Innopharma Screening Platform, Biofarma Research group, Centre of Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain

5. Department of Cellular Biology, Genetics and Physiology, Faculty of Sciences, University of Málaga, Campus de Teatinos, 29071 Málaga, Spain

6. Department of Inorganic Chemistry, Faculty of Sciences, University of Málaga, Campus de Teatinos, 29071 Málaga, Spain

Funder

European Regional Development Fund

Ministerio de Econom?a y Competitividad

Xunta de Galicia

Funda??o para a Ci?ncia e a Tecnologia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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