Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space-Reference-Cited by-同舟云学术

Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space

Published:2021-12-13 Issue:24 Volume:64 Page:17887-17900
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Piticchio Serena G.¹,Martínez-Cartró Míriam¹,Scaffidi Salvatore¹,Rachman Moira¹,Rodriguez-Arevalo Sergio²,Sanchez-Arfelis Ainoa²,Escolano Carmen²^ORCID,Picaud Sarah³,Krojer Tobias³,Filippakopoulos Panagis³,von Delft Frank³⁴⁵⁶⁷^ORCID,Galdeano Carles¹,Barril Xavier¹⁸^ORCID

Affiliation:

1. Departament de Farmacia i Tecnología Farmacèutica, i Fisicoquímica, Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain

2. Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain

3. Structural Genomics Consortium, Nuffield Department of Medicine, Oxford University, Old Road Campus Research Building, Roosevelt Drive, OX3 7DQ Oxford, United Kingdom

4. Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot OX11 0QX, United Kingdom

5. Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, United Kingdom

6. Centre for Medicines Discovery, University of Oxford, Oxford OX1 3QU, United Kingdom

7. Department of Biochemistry, University of Johannesburg, Auckland Park 2006, South Africa

8. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain

Funder

Medical Research Council

Ministerio de Ciencia e Innovaci??n

Ag??ncia de Gesti?? d???Ajuts Universitaris i de Recerca

H2020 Marie Sk??odowska-Curie Actions

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01108

Reference83 articles.

1. Twenty years on: the impact of fragments on drug discovery

2. Current perspectives in fragment-based lead discovery (FBLD)

3. Fragment-to-Lead Medicinal Chemistry Publications in 2015

4. Fragment-to-Lead Medicinal Chemistry Publications in 2016

5. Fragment-to-Lead Medicinal Chemistry Publications in 2017

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