Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy-Reference-Cited by-同舟云学术

Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy

Published:2021-05-24 Issue:11 Volume:64 Page:7189-7209
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Yue¹,Li Zhihong¹^ORCID,McDonough Michael A.²,Schofield Christopher J.²^ORCID,Zhang Xiaojin¹^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Drug Design and Optimization, and Department of Chemistry, China Pharmaceutical University, Nanjing 211198, China

2. Chemistry Research Laboratory, Department of Chemistry and the Ineos Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom

Funder

National Natural Science Foundation of China

the Six Talent Peaks Project of Jiangsu Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00415

Reference119 articles.

1. Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

2. The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

3. The Nobel Prize Home Page. https://www.nobelprize.org/prizes/medicine/2019/advanced-information/ (accessed March 2, 2021).

4. Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

5. New horizons in hypoxia signaling pathways

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