Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis

Author:

Che Jinxin1,Jin Zegao1,Yan Fangjie23,You Jieqiong2,Xie Jiangfeng1,Chen Binhui1,Cheng Gang4ORCID,Zhu Hong25,He Qiaojun1235,Hu Yongzhou1ORCID,Yang Bo23,Cao Ji235,Dong Xiaowu135ORCID

Affiliation:

1. Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China

2. Institute of Pharmacology & Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China

3. Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou 310018, P. R. China

4. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, P. R. China

5. Cancer Center, Zhejiang University, Hangzhou 310058, P. R. China

Funder

National Natural Science Foundation of China

Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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