Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides-Reference-Cited by-同舟云学术

Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides

Published:2022-03-18 Issue:7 Volume:65 Page:5701-5723
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Khirsariya Prashant¹²^ORCID,Pospíšil Patrik¹,Maier Lukáš¹²,Boudný Miroslav³⁴,Babáš Martin³,Kroutil Ondřej³,Mráz Marek³⁴,Vácha Robert³^ORCID,Paruch Kamil¹²^ORCID

Affiliation:

1. Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic

2. International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne’s University Hospital in Brno, 602 00 Brno, Czech Republic

3. Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic

4. Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavska 20, 625 00 Brno, Czech Republic

Funder

Bader Philanthropies

European Commission

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

Grantov? Agentura Cesk? Republiky

Ministerstvo Zdravotnictv? Cesk? Republiky

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02228