A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry <i>In Vitro</i> and <i>In Vivo</i>-Reference-Cited by-同舟云学术

A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry In Vitro and In Vivo

Published:2022-01-03 Issue:1 Volume:65 Page:552-561
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Adam Catherine¹,Bray Thomas L.¹,Pérez-López Ana M.¹^ORCID,Tan Ee Hong²³,Rubio-Ruiz Belén¹^ORCID,Baillache Daniel J.¹^ORCID,Houston Douglas R.⁴^ORCID,Salji Mark J.²³,Leung Hing Y.²³,Unciti-Broceta Asier¹^ORCID

Affiliation:

1. Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, EH4 2XU Edinburgh, U.K.

2. Institute of Cancer Sciences, University of Glasgow, Bearsden, Glasgow G61 1QH, U.K.

3. Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow G61 1BD, U.K.

4. Institute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh EH9 3BF, U.K.

Funder

Engineering and Physical Sciences Research Council

Medical Research Council

Medical Research Scotland

University Of Edinburgh

H2020 Marie Sk??odowska-Curie Actions

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01733

Reference46 articles.

1. Uridine triacetate for lethal 5-FU toxicity due to dihydropyrimidine dehydrogenase (DPD) deficiency.

2. 5-fluorouracil and cardiotoxicity: a review

3. DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report

4. Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: Ready for prime time

5. U.S. Food & Drug Administration. Table of pharmacogenetic associations, revised May 24, 2021. https://www.fda.gov/medical-devices/precision-medicine/table-pharmacogenetic-associations.

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