Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1-Reference-Cited by-同舟云学术

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Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1

Published:2021-10-11 Issue:20 Volume:64 Page:15126-15140
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zaienne Daniel¹,Willems Sabine¹^ORCID,Schierle Simone¹,Heering Jan²^ORCID,Merk Daniel¹³^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, D-60438 Frankfurt, Germany

2. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, D-60596 Frankfurt, Germany

3. Department of Pharmacy, Ludwig-Maximilians-Universität München, D-81377 Munich, Germany

Funder

Aventis Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01077

Reference40 articles.

1. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

2. NURR1 in Parkinson disease—from pathogenesis to therapeutic potential

3. Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models

4. Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease

5. Nurr1 (NR4A2) regulates Alzheimer’s disease-related pathogenesis and cognitive function in the 5XFAD mouse model

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1. The roles of orphan nuclear receptor 4 group A1 and A2 in fibrosis;International Immunopharmacology;2024-09

2. Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism;Journal of Medicinal Chemistry;2024-07-31

3. Development of a Potent Nurr1 Agonist Tool for In Vivo Applications;Journal of Medicinal Chemistry;2023-04-26

4. Opportunities and challenges in targeting orphan nuclear receptors;Chemical Communications;2023

5. Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands;Bioorganic Chemistry;2022-12

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