Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase-Reference-Cited by-同舟云学术

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Published:2021-11-22 Issue:23 Volume:64 Page:17146-17183
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bagal Sharan K.¹^ORCID,Gregson Clare¹,O’ Donovan Daniel H.¹,Pike Kurt G.¹^ORCID,Bloecher Andrew²,Barton Peter¹,Borodovsky Alexandra²,Code Erin²,Fillery Shaun M.¹^ORCID,Hsu Jessie Hao-Ru²,Kawatkar Sameer P.²,Li Chengzhi³,Longmire David¹,Nai Youfeng³,Nash Samuel C.¹,Pike Andrew¹,Robinson James¹^ORCID,Read Jon A.¹,Rawlins Phillip B.¹,Shen Minhui²,Tang Jia³,Wang Peng³,Woods Haley²,Williamson Beth¹

Affiliation:

1. AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom

2. AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

3. Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01161

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1. Epigenetic plasticity and the hallmarks of cancer