Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action-Reference-Cited by-同舟云学术

Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action

Published:2021-10-22 Issue:21 Volume:64 Page:15727-15746
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zerio Christopher J.¹^ORCID,Cunningham Tyler A.²,Tulino Allison S.¹,Alimusa Erin A.¹,Buckley Thomas M.¹,Moore Kohlson T.¹,Dodson Matthew¹,Wilson Nathan C.¹,Ambrose Andrew J.¹^ORCID,Shi Taoda¹,Sivinski Jared¹,Essegian Derek J.²,Zhang Donna D.¹,Schürer Stephan C.²³^ORCID,Schatz Jonathan H.⁴³,Chapman Eli¹^ORCID

Affiliation:

1. College of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel Street, P.O. Box 210207, Tucson, Arizona 85721, United States

2. Miller School of Medicine, Department of Molecular and Cellular Pharmacology, University of Miami, 1600 NW 10th Avenue, Miami, Florida 33136, United States

3. Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Avenue, Miami, Florida 33136, United States

4. Miller School of Medicine, Department of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, Florida 33136, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01014

Reference46 articles.

1. Targeting the translation machinery in cancer

2. Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment

3. The Organizing Principles of Eukaryotic Ribosome Recruitment