Synthesis, Characterization, and Preclinical Evaluation of a Small-Molecule Prostate-Specific Membrane Antigen-Targeted Monomethyl Auristatin E Conjugate

Author:

Machulkin Aleksei E.1ORCID,Uspenskaya Anastasia A.1,Zyk Nikolay U.1,Nimenko Ekaterina A.1,Ber Anton P.1,Petrov Stanislav A.1,Polshakov Vladimir I.2,Shafikov Radik R.13,Skvortsov Dmitry A.1,Plotnikova Ekaterina A.4ORCID,Pankratov Andrei A.4,Smirnova Galina B.5,Borisova Yulia A.5,Pokrovsky Vadim S.56,Kolmogorov Vasilii S.7,Vaneev Alexander N.7,Khudyakov Alexander D.1,Chepikova Olga E.8,Kovalev Sergey1ORCID,Zamyatnin Jr Andrey A.891011,Erofeev Alexander7,Gorelkin Petr7,Beloglazkina Elena K.1ORCID,Zyk Nikolay V.1,Khazanova Elena S.12,Majouga Alexander G.1713ORCID

Affiliation:

1. Chemistry Department, Lomonosov Moscow State University, Building 1/3, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation

2. Center for Magnetic Tomography and Spectroscopy, Faculty of Fundamental Medicine, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation

3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, Moscow 117997, Russian Federation

4. National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 2 Botkinskiy Proezd, 3, Moscow 125284, Russian Federation

5. N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russian Federation

6. RUDN University, Miklukho-Maklaya Street 6, Moscow 117198, Russian Federation

7. National University of Science and Technology MISiS, 9 Leninskiy Prospekt, Moscow 119049, Russian Federation

8. Department of Biotechnology, Sirius University of Science and Technology, 1 Olympic Avenue, Sochi 354340, Russian Federation

9. Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Trubetskaya Street 8-2, Moscow 119991, Russian Federation

10. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow 119992, Russian Federation

11. Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, U.K.

12. LLC Izvarino-Pharma, v. Vnukovskoe, Vnukovskoe Shosse, Fifth km., Building 1, Moscow 108817, Russian Federation

13. Dmitry Mendeleev University of Chemical Technology of Russia, Miusskaya Square 9, Moscow 125047, Russian Federation

Funder

Russian Science Foundation

Russian Foundation for Basic Research

Ministry of Education and Science of the Russian Federation

Interdisciplinary Scientific and Educational School, Moscow University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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