Design, Synthesis, and Biological Evaluation of Potent EZH2/LSD1 Dual Inhibitors for Prostate Cancer-Reference-Cited by-同舟云学术

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Design, Synthesis, and Biological Evaluation of Potent EZH2/LSD1 Dual Inhibitors for Prostate Cancer

Published:2024-08-28 Issue:17 Volume:67 Page:15586-15605
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Le Meiling¹,Lu Wenhua¹,Tan Xiaozhuo¹,Luo Bingling¹,Yu Tiantian¹,Sun Yameng¹,Guo Zhirong¹,Huang Peng¹,Zhu Daqian²,Wu Qiang³,Ganesan A.⁴^ORCID,Wen Shijun¹^ORCID

Affiliation:

1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

2. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China

3. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa 999078, Macau

4. School of Chemistry, Pharmacy & Pharmacology, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom

Funder

Science and Technology Planning Project of Guangdong Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01250

Reference49 articles.

1. Cancer Epigenetics: From Mechanism to Therapy

2. Epigenetic modifications of histones in cancer

3. Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation

4. Targeting EZH2 in cancer

5. Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective

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