Imaging and Monitoring HER2 Expression in Tumors during HER2 Antibody–Drug Conjugate Therapy Utilizing a Radiolabeled Site-Specific Single-Domain Antibody Probe: <sup>68</sup>Ga-NODAGA-SNA004-GSC-Reference-Cited by-同舟云学术

Imaging and Monitoring HER2 Expression in Tumors during HER2 Antibody–Drug Conjugate Therapy Utilizing a Radiolabeled Site-Specific Single-Domain Antibody Probe: ⁶⁸Ga-NODAGA-SNA004-GSC

Published:2024-07-30 Issue:15 Volume:67 Page:12855-12867
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ge Shushan¹²³^ORCID,Wang Chao⁴,You Xuyang⁵,He Huihui⁶,Zhang Bin¹,Jia Tongtong¹,Cai Xiaowei⁷,Sang Shibiao¹,Xu Tao⁴,Deng Shengming¹³

Affiliation:

1. Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China

2. Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215006, China

3. Nuclear Medicine Laboratory of Mianyang Central Hospital, Mianyang 621099, China

4. Smart-Nuclide Biotech, No. 218 Xing-Hu Road, Suzhou, 215125, China

5. Department of Nuclear Medicine, Suzhou Ninth People’s Hospital, Suzhou 215006, China

6. Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University, Wuxi 214062, China

7. Department of Nuclear Medicine, The Affiliated Suqian First People’s Hospital of Nanjing Medical University, Suqian 223812, China

Funder

State Key Laboratory of Radiation Medicine and Protection

Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions

National Natural Science Foundation of China

Jiangsu Commission of Health

Suqian Science and Technology Program

Suzhou Science and Education Youth Project

Gusu Health Talent Program

National Engineering Research Center of Isotopes and Drugs

NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00857

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4. The benefit of HER2-targeted therapies on overall survival of patients with metastatic HER2-positive breast cancer – a systematic review

5. Targeting HER2-positive breast cancer: advances and future directions