Hit-to-Lead Optimization of Heterocyclic Carbonyloxycarboximidamides as Selective Antagonists at Human Adenosine A3 Receptor-Reference-Cited by-同舟云学术

Hit-to-Lead Optimization of Heterocyclic Carbonyloxycarboximidamides as Selective Antagonists at Human Adenosine A3 Receptor

Published:2024-07-29 Issue:15 Volume:67 Page:13117-13146
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Xianglin¹,Chorianopoulou Anna²^ORCID,Kalkounou Panagoula²,Georgiou Maria²,Pousias Athanasios²,Davies Amy¹,Pearce Abigail¹^ORCID,Harris Matthew¹,Lambrinidis George²^ORCID,Marakos Panagiotis²,Pouli Nicole²,Kolocouris Antonios²^ORCID,Lougiakis Nikolaos²,Ladds Graham¹^ORCID

Affiliation:

1. Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.

2. Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou 15771, Athens, Greece

Funder

Royal Society

China Scholarship Council

Cambridge Trust

Biotechnology and Biological Sciences Research Council

Chiesi Hellas

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01092

Reference106 articles.

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4. Adenosine receptors and renal ischaemia reperfusion injury

5. A3Adenosine receptors mediate oligodendrocyte death and ischemic damage to optic nerve