Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors-Reference-Cited by-同舟云学术

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Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors

Published:2024-07-02 Issue:13 Volume:67 Page:11273-11295
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Foster Daniel J.¹,Dunnavant Kyle¹,Shrader Christopher W.¹,LoPresti Marion²,Seay Sarah¹,Kharel Yugesh³,Brown Anne M.²^ORCID,Huang Tao³,Lynch Kevin R.³^ORCID,Santos Webster L.¹^ORCID

Affiliation:

1. Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, United States

2. Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, United States

3. Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, United States

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00879

Reference61 articles.

1. Benefit–Risk Profile of Sphingosine-1-Phosphate Receptor Modulators in Relapsing and Secondary Progressive Multiple Sclerosis

2. Efficacy and Safety of S1P1 Receptor Modulator Drugs for Patients with Moderate-to-Severe Ulcerative Colitis

3. Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

4. Get me out of here: Sphingosine 1‐phosphate signaling and T cell exit from tissues during an immune response

5. S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes

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