Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity-Reference-Cited by-同舟云学术

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Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity

Published:2024-06-06 Issue:12 Volume:67 Page:10012-10024
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miao Ya¹,Virtanen Anniina¹²,Zmajkovic Jakub³,Hilpert Morgane³,Skoda Radek C.³,Silvennoinen Olli¹²,Haikarainen Teemu¹⁴^ORCID

Affiliation:

1. Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland

2. Institute of Biotechnology, HiLIFE, University of Helsinki, 00790 Helsinki, Finland

3. Experimental Hematology, Department of Biomedicine, University Hospital Basel and University of Basel, 4056 Basel, Switzerland

4. Fimlab Laboratories, 33520 Tampere, Finland

Funder

Sigrid Jus?liuksen S??ti?

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Swiss Cancer Research Foundation

Tampereen Tuberkuloosis??ti?

Tays

Research Council of Finland

Jane ja Aatos Erkon S??ti?

Sy?p?s??ti?

Stiftung f?r H?matologische Forschung

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00197

Reference53 articles.

1. JAKS AND STATS: Biological Implications

2. Signaling Through the Hematopoietic Cytokine Receptors

3. The regulation of JAKs in cytokine signaling and its breakdown in disease

4. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

5. Epidemiology of myeloproliferative neoplasms in the United States

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1. JAK inhibitor selectivity: new opportunities, better drugs?;Nature Reviews Rheumatology;2024-09-09

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