Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety

Author:

Pero Joseph E.1ORCID,Mueller Elizabeth A.2,Adams Ashley M.1,Adolph Ramona S.3ORCID,Bagchi Parikshit2,Balce Dale2,Bantscheff Marcus3ORCID,Barauskas Ona2,Bartha Istvan2,Bohan Dana2,Cai Haiying2,Carabajal Esteban2,Cassidy James2,Cato Matthew1,Chaudhary Khuram W.1,Chen Dingjun2,Chen Yi-Pei2,Colas Christophe2,Darwech Isra2,Eberl H. Christian3ORCID,Fernandez Beth2,Gordon Earl1,Grosse Johannes2,Hansen Justin2,Hetzler Belinda2ORCID,Hwang Seungmin2,Jeyasingh Sam2,Kowalski Beatriz2,Lehmann Stephanie3,Lo Gary2,McAllaster Michael2,McHugh Charles1,Momont Corey2,Newby Zachary2,Nigro Maria2,Oladunni Fatai2,Pannirselvam Malar1,Park Arnold2,Pearson Neil1,Peat Andrew J.1,Plastridge Bob2,Ranjan Rohit2,Safabakhsh Pegah2,Shapiro Nathan D.2,Soriaga Leah2,Stokes Neil1,Sweeney David2,Talecki Lindsey1ORCID,Telenti Amalio2,Terrell Ashley2,Tse Winston2,Wang Lisha2,Wang Shuya1,Wedel Laura2,Werner Thilo3,Dalmas Wilk Deidre1,Yim Samantha2,Zhou Jiayi2

Affiliation:

1. GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

2. Vir Biotechnology, Inc., 1800 Owens St., San Francisco, California 94158, United States

3. Cellzome GmbH, a GSK company, Meyerhofstrasse 1, 69117 Heidelberg, Germany

Funder

Vir Biotechnology

GlaxoSmithKline

Publisher

American Chemical Society (ACS)

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