Molecular Transformers: Adaptive Multitarget Ligands for Esterase-Induced Transition from Analgesics to Anesthetics-Reference-Cited by-同舟云学术

Molecular Transformers: Adaptive Multitarget Ligands for Esterase-Induced Transition from Analgesics to Anesthetics

Published:2024-07-16 Issue:14 Volume:67 Page:12349-12365
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Tianguang¹,Song Chi¹,Chen Yuhao²,Gan Yu¹,Hu Shilong¹,Hai Ao¹,Liu Wencheng¹,Kang Ting¹,Zhao Yi¹,Miao Zhuang¹,Wang Xing²,Fu Yihang³,Ke Bowen¹^ORCID

Affiliation:

1. Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

2. West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China

3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China

Funder

Science and Technology Department of Tibet Autonomous Region

West China Hospital, Sichuan University

Science and Technology Department of Sichuan Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01044

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4. Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D₃ (D₃R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics

5. Dual‐target inhibitors of bromodomain and extra‐terminal proteins in cancer: A review from medicinal chemistry perspectives