Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis-Reference-Cited by-同舟云学术

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Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis

Published:2024-08-22 Issue:17 Volume:67 Page:15711-15737
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fu Zhiyuan¹,Duan Yangqin¹,Pei Heying¹,Zou Yurong¹,Tang Minghai¹,Chen Yong²,Yang Tao¹^ORCID,Ma Ziyan¹,Yan Wei¹,Su Kaiyue¹,Cai Xiaoying¹,Guo Tao¹,Teng Yaxin¹,Jia Tao³,Chen Lijuan¹³^ORCID

Affiliation:

1. Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

2. Innovation Center of Nursing Research and Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China

3. Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu 610041, China

Funder

West China Hospital, Sichuan University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01341

Reference66 articles.

1. The NLRP3 inflammasome: molecular activation and regulation to therapeutics

2. Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction

3. Targeting the NLRP3 inflammasome in inflammatory diseases

4. A critical role for the NLRP3 inflammasome in NASH

5. Gout-associated uric acid crystals activate the NALP3 inflammasome

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