Drug Repurposing of ACT001 to Discover Novel Promising Sulfide Prodrugs with Improved Safety and Potent Activity for Neutrophil-Mediated Antifungal Immunotherapy

Author:

Lu Xiangran1,Wang Rongrong1,Yu Yao1,Wei Jinlian2,Xu Yixiang2,Zhou Luoyifan2,Mao Fei2ORCID,Li Jian1234ORCID,Li Xiaokang2,Jia Xinming1ORCID

Affiliation:

1. Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, China

2. State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

3. Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan, College of Pharmacy, Dali University, Dali 671000, China

4. Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Pharmacy, Hainan University, Haikou 570228, China

Funder

National Key Research and Development Program of China

Shanghai Municipal Education Commission

State Key Laboratory of Bioreactor Engineering

Science and Technology Commission of Shanghai Municipality

Shanghai Municipal Health Commission

National Natural Science Foundation of China

Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism

Shanghai laboratory animal research fund

Publisher

American Chemical Society (ACS)

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