Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3′-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury

Author:

Chen Mingjie12,Lei Shuyue34,Zhou Zihua12,Wang Meng5,Feng Chunlan34,Gao Xiaoling12ORCID,Ding Chunyong12ORCID,Song Zilan12,Tang Wei34,Zhang Ao12ORCID

Affiliation:

1. Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China

2. National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China

3. State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

4. University of Chinese Academy of Sciences, Beijing 100049, China

5. School of Medicine, Anhui University of Science and Technology, Huainan 232001, China

Funder

Innovative Research Team of High-level Local University in Shanghai

National Natural Science Foundation of China

National Innovation of Science and Technology of China

Shanghai Zhang Jiang National Independent Innovation of China

Publisher

American Chemical Society (ACS)

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