Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500)-Reference-Cited by-同舟云学术

Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500)

Published:2024-02-01 Issue:4 Volume:67 Page:2349-2368
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Black W. Cameron¹^ORCID,Abdoli Abbas²,An Xiuli³,Auger Anick⁴,Beaulieu Patrick⁵,Bernatchez Michel⁵,Caron Cathy¹,Chefson Amandine⁴,Crane Sheldon²,Diallo Mohamed¹,Dorich Stéphane⁴,Fader Lee D.⁴,Ferraro Gino B.¹,Fournier Sara¹,Gao Qi⁶,Ginzburg Yelena⁷,Hamel Martine¹,Han Yongshuai³,Jones Paul²,Lanoix Stéphanie²,Lacbay Cyrus M.²,Leclaire Marie-Eve¹,Levy Maayan⁷,Mamane Yael¹,Mulani Amina²,Papp Robert¹,Pellerin Charles⁴,Picard Audrey⁴,Skeldon Alexander⁴,Skorey Kathryn²,Stocco Rino¹,St.-Onge Miguel⁴,Truchon Jean-François¹,Truong Vouy Linh²,Zimmermann Michal¹,Zinda Michael¹,Roulston Anne¹

Affiliation:

1. Repare Therapeutics, Inc., 7171 Frederick-Banting, Building 2, Saint-Laurent, Quebec H4S 1Z9, Canada

2. Nuchem Sciences, Inc., 2350 Rue Cohen, Suite 201, Saint-Laurent, Quebec H4R 2N6, Canada

3. New York Blood Center Enterprises, New York, New York 10065, United States

4. Ventus Therapeutics, Inc., 7150 Frederick-Banting, Saint-Laurent, Quebec H4S 2A1, Canada

5. OmegaChem, 480 Rue Perreault, Lévis, Quebec G6W 7V6, Canada

6. J-Star Research, Inc., 3001 Hadley Road, Suites 1-5A, South Plainfield, New Jersey 07080, United States

7. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01917

Reference49 articles.

1. Synthetic Lethality in Cancer Therapeutics: The Next Generation

2. Synthetic lethality and cancer

3. Recent advances in DDR (DNA damage response) inhibitors for cancer therapy

4. The essential kinase ATR: ensuring faithful duplication of a challenging genome

5. A consensus set of genetic vulnerabilities to ATR inhibition

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies;Journal of Medicinal Chemistry;2024-07-25

2. New Horizons of Synthetic Lethality in Cancer: Current Development and Future Perspectives;Journal of Medicinal Chemistry;2024-07-02

3. Identification and Biosynthesis of anN-Glucuronide Metabolite of Camonsertib;Drug Metabolism and Disposition;2024-02-20