Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2)-Reference-Cited by-同舟云学术

Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2)

Published:2023-11-27 Issue:23 Volume:66 Page:15750-15760
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Young¹,Whitefield Brandon¹,Nevius Erin²,Hill Mark²,DelRosario Joselyn¹,Sinitsyna Nadia¹,Shanmugasundaram Veerabahu³,Mukherjee Debarati⁴,Shi Lihong¹,Mayne Christopher Glenn¹,Rousseau Anne-Marie²,Bernard Steffen M.⁵^ORCID,Buenviaje Jennifer¹,Khambatta Gody¹,El Samin Miriam³,Wallace Michael⁵,Nie Zhe⁵,Sivakumar Pallavur²,Hamann Lawrence G.³,McDonnell Donald P.⁴,D’Agostino Laura Akullian³^ORCID

Affiliation:

1. Bristol Myers Squibb, 10300 Campus Point Drive, San Diego, California 92121, United States

2. Bristol Myers Squibb, 424 Dexter Ave. N. Seattle, Seattle, Washington 98109, United States

3. Bristol Myers Squibb, 200 Cambridge Park Drive, Cambridge, Massachusetts 02142, United States

4. Dept of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710, United States

5. Celgene, 10300 Campus Point Drive, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01137

Reference33 articles.

1. In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

2. Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology

3. The Ca 2+ /Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft

4. A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway

5. Differential AMP-activated Protein Kinase (AMPK) Recognition Mechanism of Ca2+/Calmodulin-dependent Protein Kinase Kinase Isoforms