Structure–Activity Relationship Study of Cannabidiol-Based Analogs as Negative Allosteric Modulators of the μ-Opioid Receptor-Reference-Cited by-同舟云学术

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Structure–Activity Relationship Study of Cannabidiol-Based Analogs as Negative Allosteric Modulators of the μ-Opioid Receptor

Published:2023-07-12 Issue:14 Volume:66 Page:9466-9494
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bosquez-Berger Taryn¹,Gudorf Jessica A.²^ORCID,Kuntz Charles P.²,Desmond Jacob A.²,Schlebach Jonathan P.²^ORCID,VanNieuwenhze Michael S.²^ORCID,Straiker Alex¹

Affiliation:

1. Gill Center for Biomolecular Science, Department of Psychological and Brain Sciences, Program in Neuroscience, Indiana University, Bloomington, Indiana 47405, United States

2. Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States

Funder

Indiana University

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00061

Reference64 articles.

1. Current Research on Opioid Receptor Function

2. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

3. Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance

4. Basic opioid pharmacology: an update

5. CDC Opioid Data Analysis and Resources, < https://www.cdc.gov/opioids/data/analysis-resources.html> (2021).

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