Design and Pharmacological Chaperone Effects of <i>N</i>-(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase-Reference-Cited by-同舟云学术

Design and Pharmacological Chaperone Effects of N-(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase

Published:2023-06-14 Issue:13 Volume:66 Page:9023-9039
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kato Atsushi¹^ORCID,Nakagome Izumi²,Kise Maki¹,Yoshimura Kousuke¹,Tanaka Nobutada²^ORCID,Nash Robert J.³^ORCID,Fleet George W. J.⁴,Kobayashi Yota⁵,Ikeda Hayato⁶,Okada Takuya⁵⁶^ORCID,Toyooka Naoki⁵⁶^ORCID

Affiliation:

1. Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

2. School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan

3. Institute of Biological, Environmental and Rural Sciences / Phytoquest Limited, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, U.K.

4. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.

5. Graduate School of Pharma-Medical Sciences, University of Toyama, Toyama 930-8555, Japan

6. Faculty of Engineering, University of Toyama, Toyama 930-8555, Japan

Funder

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00637

Reference51 articles.

1. Amino-sugar glycosidase inhibitors: versatile tools for glycobiologists

2. Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application

3. Iminosugars as therapeutic agents: recent advances and promising trends

4. Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

5. Pharmacological chaperone therapy for Fabry disease

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