Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides-Reference-Cited by-同舟云学术

Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides

Published:2019-01-07 Issue:3 Volume:62 Page:1455-1467
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Merlino Francesco¹^ORCID,Billard Étienne²,Yousif Ali M.¹,Di Maro Salvatore¹^ORCID,Brancaccio Diego¹,Abate Luigi¹,Carotenuto Alfonso¹^ORCID,Bellavita Rosa¹,d’Emmanuele di Villa Bianca Roberta¹,Santicioli Paolo³,Marinelli Luciana¹^ORCID,Novellino Ettore¹^ORCID,Hébert Terence E.⁴,Lubell William D.⁵,Chatenet David²^ORCID,Grieco Paolo¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Naples “Federico II”, via D. Montesano 49, Naples 80131, Italy

2. INRS—Institut Armand-Frappier, Groupe de Recherche en Ingénierie des Peptides et en Pharmacothérapie (GRIPP), Université du Québec, 531 Boulevard des Prairies, Ville de Laval, Québec H7V 1B7, Canada

3. Department of Pharmacology, Menarini Ricerche, via Rismondo 12/A, Florence 50131, Italy

4. Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec H3A 1A3, Canada

5. Département de Chimie, Université de Montréal, C.P. 6128, Station Centre-ville, Montréal, Québec H3C 3J7, Canada

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01601

Reference83 articles.

1. Strategic Approaches to Optimizing Peptide ADME Properties

2. Current challenges in peptide-based drug discovery

3. Recent Advances Toward the Discovery of Drug-Like Peptides De novo

4. N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

5. Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

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