Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)-Reference-Cited by-同舟云学术

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

Published:2018-10-05 Issue:21 Volume:61 Page:9691-9721
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wehn Paul M.¹^ORCID,Rizzi James P.¹,Dixon Darryl D.¹^ORCID,Grina Jonas A.¹,Schlachter Stephen T.¹,Wang Bin¹,Xu Rui¹,Yang Hanbiao¹,Du Xinlin¹,Han Guangzhou¹,Wang Keshi¹,Cao Zhaodan¹,Cheng Tzuling¹,Czerwinski Robert M.¹,Goggin Barry S.¹,Huang Heli¹,Halfmann Megan M.¹,Maddie Melissa A.¹,Morton Emily L.¹,Olive Sarah R.¹,Tan Huiling¹,Xie Shanhai¹,Wong Tai¹,Josey John A.¹,Wallace Eli M.¹

Affiliation:

1. Peloton Therapeutics, Inc., 2330 Inwood Road, Suite 226, Dallas, Texas 75235, United States

Funder

Cancer Prevention and Research Institute of Texas

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01196

Reference36 articles.

1. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.