Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)-Reference-Cited by-同舟云学术

Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)

Published:2018-09-24 Issue:1 Volume:62 Page:342-358
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bollinger Sean R.¹²,Engers Darren W.¹²,Panarese Joseph D.¹²,West Mary¹²,Engers Julie L.¹²,Loch Matthew T.¹²,Rodriguez Alice L.¹²,Blobaum Anna L.¹²,Jones Carrie K.¹²,Thompson Gray Analisa¹²,Conn P. Jeffrey¹²³,Lindsley Craig W.¹²⁴⁵^ORCID,Niswender Colleen M.¹²³,Hopkins Corey R.¹²⁴^ORCID

Affiliation:

1. Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States

2. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States

3. Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States

4. Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States

5. Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States

Funder

William K. Warren Foundation

Bristol-Myers Squibb

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00994

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