Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines-Reference-Cited by-同舟云学术

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Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines

Published:2018-09-05 Issue:18 Volume:61 Page:8457-8467
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dianati Vahid¹,Kwiatkowska Anna²^ORCID,Couture Frédéric²,Desjardins Roxane²,Dory Yves L.¹^ORCID,Day Robert²^ORCID

Affiliation:

1. Département de Chimie, Faculté des Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada

2. Département de Chirurgie/Urologie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada

Funder

Canadian Institutes of Health Research

Prostate Cancer Canada

Canadian Cancer Society Research Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01144

Reference36 articles.

1. PACE4: a subtilisin-like endoprotease with unique properties

2. Proprotein convertase inhibition: Paralyzing the cell’s master switches

3. Molecular Validation of PACE4 as a Target in Prostate Cancer

4. PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer

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1. Enhancing the Drug-Like Profile of a Potent Peptide PACE4 Inhibitor by the Formation of a Host–Guest Inclusion Complex with β-Cyclodextrin;Molecular Pharmaceutics;2023-08-09

2. N‐Boc‐Protected α‐Amino Acids by 1,3‐Migratory Nitrene C(sp³)−H Insertion;European Journal of Organic Chemistry;2023-05-26

3. The chemistry and biology of guanidine secondary metabolites;Natural Product Reports;2021

4. Mouse Models of Human Proprotein Convertase Insufficiency;Endocrine Reviews;2020-12-31

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