Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity-Reference-Cited by-同舟云学术

Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity

Published:2018-11-09 Issue:23 Volume:61 Page:10834-10859
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Messore Antonella¹^ORCID,Madia Valentina Noemi¹^ORCID,Pescatori Luca¹^ORCID,Saccoliti Francesco¹^ORCID,Tudino Valeria¹^ORCID,De Leo Alessandro¹,Bortolami Martina¹^ORCID,De Vita Daniela¹^ORCID,Scipione Luigi¹,Pepi Federico¹,Costi Roberta¹,Rivara Silvia²^ORCID,Scalvini Laura²^ORCID,Mor Marco²^ORCID,Ferrara Fabiana Fosca³,Pavoni Emiliano³,Roscilli Giuseppe³,Cassinelli Giuliana⁴,Milazzo Ferdinando M.⁵,Battistuzzi Gianfranco⁵,Di Santo Roberto¹^ORCID,Giannini Giuseppe⁵

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, “Sapienza” Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy

2. Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I- 43124 Parma, Italy

3. Takis S.R.L., Via Castel Romano 100, I-00128 Roma, Italy

4. Dipartimento di Ricerca Applicata e Sviluppo Tecnologico, Unità di Farmacologia Molecolare, Fondazione IRCCS Istituto Nazionale dei Tumori, via Amadeo 42, I-20133 Milano, Italy

5. R&D Alfasigma S.p.A., Via Pontina Km 30,400, Pomezia, I-00071 Roma, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01497

Reference62 articles.

1. Heparanase: a key enzyme involved in cell invasion

2. Processing of the Human Heparanase Precursor and Evidence That the Active Enzyme Is a Heterodimer

3. Heparanase Affects Food Intake and Regulates Energy Balance in Mice

4. Heparan sulphate proteoglycans: the sweet side of development

5. Getting Neointimal

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