Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor-Reference-Cited by-同舟云学术

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor

Published:2017-03-29 Issue:9 Volume:60 Page:3851-3865
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mandal Mihirbaran¹^ORCID,Tan Zheng¹,Madsen-Duggan Christina¹,Buevich Alexei V.¹^ORCID,Caldwell John P.¹,Dejesus Reynalda¹,Flattery Amy¹,Garlisi Charles G.¹,Gill Charles¹,Ha Sookhee Nicole¹,Ho Ginny¹,Koseoglu Sandra¹,Labroli Marc¹,Basu Kallol¹,Lee Sang Ho¹,Liang Lianzhu¹,Liu Jenny¹,Mayhood Todd¹,McGuinness Debra¹,McLaren David G.¹,Wen Xiujuan¹,Parmee Emma¹,Rindgen Diane¹,Roemer Terry¹,Sheth Payal¹,Tawa Paul¹,Tata James¹,Yang Christine¹,Yang Shu-Wei¹,Xiao Li¹,Wang Hao¹,Tan Christopher¹,Tang Haifeng¹,Walsh Paul¹,Walsh Erika¹,Wu Jin¹,Su Jing¹

Affiliation:

1. Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00113

Reference41 articles.

1. Platforms for antibiotic discovery

2. Carbapenems: Past, Present, and Future

3. The oxazolidinones: past, present, and future

4. Discovery and Development of the Monobactams

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