Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule-Reference-Cited by-同舟云学术

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Published:2017-06-06 Issue:12 Volume:60 Page:4949-4962
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cheng Xinlai¹²^ORCID,Merz Karl-Heinz¹,Vatter Sandra¹,Zeller Jochen¹,Muehlbeyer Stephan¹,Thommet Andrea¹,Christ Jochen¹,Wölfl Stefan²,Eisenbrand Gerhard¹

Affiliation:

1. Department of Chemistry, Division of Food Chemistry and Toxicology, University of Kaiserslautern, Erwin-Schrödinger-Strasse 52, D-67663 Kaiserslautern, Germany

2. Department of Pharmacy and Molecular Biotechnology, Division of Pharmaceutical Biology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00324

Reference46 articles.

1. The Role of Indirubins in Inflammation and Associated Tumorigenesis

2. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

3. GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins