Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss-Reference-Cited by-同舟云学术

Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss

Published:2017-10-27 Issue:1 Volume:61 Page:84-97
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chowdhury Sarwat,Owens Kelly N.¹,Herr R. Jason²,Jiang Qin²,Chen Xinchao²,Johnson Graham³⁴,Groppi Vincent E.⁵,Raible David W.¹⁶,Rubel Edwin W¹,Simon Julian A.^ORCID

Affiliation:

1. Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, United States

2. AMRI, Albany, New York 12203, United States

3. NuPharmAdvise LLC, Sanbornton, New Hampshire 03269 United States

4. Oricula Therapeutics, Seattle, Washington 98154, United States

5. Center for Discovery of New Molecules, University of Michigan, Ann Arbor, Michigan 48109, United States

6. Department of Biological Structure, University of Washington, Seattle, Washington 98195, United States

Funder

National Institute on Deafness and Other Communication Disorders

National Institute of Neurological Disorders and Stroke

Life Sciences Discovery Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00932

Reference47 articles.

1. Challenges and Opportunities in Presbycusis

2. Mechanisms of sensorineural cell damage, death and survival in the cochlea

3. A brief history of hair cell regeneration research and speculations on the future

4. Caspase Activation in Hair Cells of the Mouse Utricle Exposed to Neomycin

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