Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions-Reference-Cited by-同舟云学术

Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions

Published:2018-04-21 Issue:9 Volume:61 Page:3984-4003
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yu Wensheng^ORCID,Tong Ling^ORCID,Selyutin Oleg,Chen Lei,Hu Bin¹,Zhong Bin¹,Hao Jinglai¹,Ji Tao¹,Zan Shuai¹,Yin Jingjun,Ruck Rebecca T.^ORCID,Curry Stephanie,McMonagle Patricia,Agrawal Sony,Rokosz Laura,Carr Donna,Ingravallo Paul,Bystol Karin,Lahser Frederick,Liu Rong,Chen Shiying,Feng Kung-I,Cartwright Mark,Asante-Appiah Ernest,Kozlowski Joseph A.

Affiliation:

1. WuXi AppTec, 288 Fute Zhong Road, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01927

Reference35 articles.

1. Global Hepatitis Report, 2017; World Health Organization, 2017; p 7.

2. Global Hepatitis Report, 2017; World Health Organization, 2017; p 12.

3. World Health Organization Home Page. http://www.who.int/mediacentre/factsheets/fs164/en/ (accessed April 20, 2018).