Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema-Reference-Cited by-同舟云学术

Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema

Published:2018-03-08 Issue:7 Volume:61 Page:2823-2836
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Teufel Daniel P.¹,Bennett Gavin¹,Harrison Helen¹,van Rietschoten Katerine¹,Pavan Silvia¹,Stace Catherine¹,Le Floch François²,Van Bergen Tine²,Vermassen Elke²,Barbeaux Philippe²,Hu Tjing-Tjing²,Feyen Jean H. M.²,Vanhove Marc²^ORCID

Affiliation:

1. Bicycle Therapeutics Limited, Building 900, Babraham Research Campus, Cambridge CB22 3AT, U.K.

2. Thrombogenics N.V., Gaston Geenslaan 1, 3001 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01625

Reference71 articles.

1. Expression of Plasma Prekallikrein mRNA in Human Nonhepatic Tissues and Cell Lineages Suggests Special Local Functions of the Enzyme

2. A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation

3. International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences

4. The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities

5. ACTIVATION OF HAGEMAN FACTOR IN SOLID AND FLUID PHASES

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