Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors

Author:

Andreev Stanislav1,Pantsar Tatu12ORCID,Tesch Roberta34ORCID,Kahlke Niclas1,El-Gokha Ahmed15,Ansideri Francesco1,Grätz Lukas6,Romasco Jenny7,Sita Giulia8,Geibel Christian9,Lämmerhofer Michael9ORCID,Tarozzi Andrea7ORCID,Knapp Stefan34ORCID,Laufer Stefan A.110ORCID,Koch Pierre16ORCID

Affiliation:

1. Institute of Pharmaceutical Sciences, Department of Medicinal and Pharmaceutical Chemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

2. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland

3. Institute for Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany

4. Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany

5. Chemistry Department, Faculty of Science, Menoufia University, Gamal Abdel-Nasser Street, 32511 Shebin El-Kom, Egypt

6. Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany

7. Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso D’Augusto 237, 47921 Rimini, Italy

8. Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy

9. Institute of Pharmaceutical Sciences, Department of Pharmaceutical (Bio-)Analysis, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

10. Tübingen Center for Academic Drug Discovery (TüCAD2), Auf der Morgenstelle 8, 72076 Tübingen, Germany

Funder

Orionin Tutkimuss????ti??

Deutsche Forschungsgemeinschaft

H2020 Marie Sk??odowska-Curie Actions

H2020 Research Infrastructures

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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