A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species-Reference-Cited by-同舟云学术

A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species

Published:2020-08-18 Issue:17 Volume:63 Page:9838-9855
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hu Shuai¹²,Sechi Mario³^ORCID,Singh Pankaj Kumar³^ORCID,Dai Lipeng⁴,McCann Sean¹,Sun Duxin⁴^ORCID,Ljungman Mats⁵,Neamati Nouri¹

Affiliation:

1. Departments of Medicinal Chemistry, College of Pharmacy, Rogel Cancer center, University of Michigan, Ann Arbor, Michigan 48109, United States

2. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari, Italy

4. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States

5. Department of Radiation Oncology, Rogel Cancer Center and Center for RNA Biomedicine, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

National Cancer Institute

Fondazione di Sardegna

Forbes Institute for Cancer Discovery, University of Michigan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01016

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