From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

Author:

Codony Sandra1,Calvó-Tusell Carla2,Valverde Elena1,Osuna Sílvia23ORCID,Morisseau Christophe4,Loza M. Isabel5,Brea José5,Pérez Concepción6,Rodríguez-Franco María Isabel6ORCID,Pizarro-Delgado Javier789,Corpas Rubén1011,Griñán-Ferré Christian12,Pallàs Mercè12ORCID,Sanfeliu Coral1011,Vázquez-Carrera Manuel789,Hammock Bruce D.4ORCID,Feixas Ferran2ORCID,Vázquez Santiago1ORCID

Affiliation:

1. Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l’Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain

2. CompBioLab Group, Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, C/ Maria Aurèlia Capmany 69, Girona 17003, Spain

3. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain

4. Department of Entomology and Nematology and Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis 95616, California, United States

5. Drug Screening Platform/Biofarma Research Group, CIMUS Research Center. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica, University of Santiago de Compostela (USC), Santiago de Compostela 15782, Spain

6. Institute of Medicinal Chemistry, Spanish National Research Council (CSIC), C/Juan de la Cierva 3, Madrid 28006, Spain

7. Pharmacology Section. Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain

8. Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, Madrid 28029, Spain

9. Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat 08950, Spain

10. Institute of Biomedical Research of Barcelona (IIBB), CSIC and IDIBAPS, Barcelona 08036, Spain

11. CIBER Epidemiology and Public Health (CIBERESP)-Instituto de Salud Carlos III, Madrid 28029, Spain

12. Pharmacology Section. Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, and Institut de Neurociències, University of Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain

Funder

National Institute of Environmental Health Sciences

Fundaci? Bosch i Gimpera

Ministerio de Econom?a, Industria y Competitividad, Gobierno de Espa?a

National Institute of Diabetes and Digestive and Kidney Diseases

European Regional Development Fund

H2020 Marie Sklodowska-Curie Actions

Xunta de Galicia

Generalitat de Catalunya

H2020 European Research Council

Universitat de Barcelona

EIT Health Spain

Institute of Biomedicine, University of Barcelona

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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