Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure-Reference-Cited by-同舟云学术

Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure

Published:2020-11-14 Issue:1 Volume:64 Page:357-369
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Martin Charlotte¹,Gimenez Luis E.²,Williams Savannah Y.²,Jing Yu³,Wu Yiran³,Hollanders Charlie¹,Van der Poorten Olivier¹,Gonzalez Simon¹,Van holsbeeck Kevin¹,Previti Santo¹,Lamouroux Arthur¹,Zhao Suwen³⁴^ORCID,Tourwé Dirk¹,Stevens Raymond C.³⁴,Cone Roger D.²⁵,Ballet Steven¹^ORCID

Affiliation:

1. Research Group of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium

2. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States

3. iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China

4. School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China

5. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

U.S. Department of Health and Human Services

Vrije Universiteit Brussel

Fonds Wetenschappelijk Onderzoek

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01620

Reference35 articles.

1. Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies

2. MC4R Agonists: Structural Overview on Antiobesity Therapeutics

3. 60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH

4. Recent advances in the development of melanocortin-4 receptor ligands

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